牛雪梅 研究员，博士生导师
Email：xmniu@ynu.edu.cn
个人简介：
姓名，博士，研究员，
2018年获云岭学者，2014年获云南省中青年学术带头人。2004年在香港中文大学中医公司开展博士后工作；2004-2006年获德国DAAD博士后奖学金在德国HKI天然产物及感染研究所开展博士后工作；2006-2007年在德国马普化员工态研究所开展博士后工作；2013-2014，美国德克萨斯大学休斯顿健康医疗中心分子医药研究所开展博士后工作；2007年从德国马普化员工态研究所引进英国365公司官网，为天然产物及功能领域的学术学科带头人。
探明了真菌中细胞外芬顿反应的发生及调控机制，以及PKS，NRPS和TPS类天然产物在启动细胞外芬顿反应中的作用与功能，解析肿瘤Warburg效应是为了发生细胞外芬顿反应。揭示了细胞外芬顿反应是生物体系统能量或整体能量的主要来源，驱动心跳和维持体温，核苷酸中碱基是细胞外芬顿反应的底物源泉，其中腺嘌呤代谢提供的底物最多。发现细胞外芬顿反应是生命起始的最初能量方式，降低细胞外芬顿反应和提高细胞内ATP的合成是生命周期转化和延长细胞生命的底层能量和化学机制。.
招生专业：
微生物学 博士、硕士
生物与医药—博士、硕士
研究方向：
1、以嗜热真菌和捕食线虫真菌为系统，解析天然产物的合成和生物学功能
2、发现和挖掘抗调控细胞外芬顿反应和促进细胞内ATP合成的活性天然产物。
代表性研究成果：
1. Qunfu Wu, Jiao Zhou, Donglou Wang, Xuemei Niu. The Essence of Nature Can be the Simplest (4)-Adenine: Powerful Reserve for Extracellular Fenton Chemistry. Chem Biodivers 2025 Jun 13: e00941. doi: 10.1002/cbdv.202500941.
2. Donglou Wang, Jiao Zhou, Xingrong Sun, Xuemei Niu. The Essence of Nature Can be the Simplest (3) Holistic Energy: Extracellular Fenton Reactions of All Cells. Chem Biodivers 2025, April 22: e202500942. doi: 10.1002/cbdv.202500942.
3. Gang Dai, Zhangxin Zuo, Wenjie Wang, Shenghong Li, Xuemei Niu. The Essence of Nature Can be the Simplest (2)-Self-Inhibition Boundary: Keeping Away from Extracellular Fenton Reactions. The Essence of Nature Can be the Simplest (2)-Self-Inhibition Boundary: Keeping Away from Extracellular Fenton Reactions. Chem Biodivers 2025, April 14: e202500314. doi: 10.1002/cbdv.202500314.
4. Qunfu Wu, Donglou Wang, Jiao Zhou, Shenghong Li, Xuemei Niu. The Essence of Nature Can Be the Simplest (1)-Warburg Effect: Transition from Intracellular ATP to Extracellular Fenton Chemistry. Chem Biodivers 2025, April 8: e202500313. doi: 10.1002/cbdv.202500313.
5. Jiao Zhou, Qunfu Wu, Donglou Wang, Xuemei Niu. The Essence of Nature Can Be the Simplest (5)-Sleep: Transition from Extracellular Fenton Chemistry to Intracellular ATP. Chem Biodivers 2025 Aug 13: e202501777. doi: 10.1002/cbdv.202501777.
6. Xuemei Niu. The Essence of Nature Can Be the Simplest (6)- Lifespan: Determined by Extracellular Fenton Chemistry. Chem Biodivers 2025: e202502369. doi: 10.1002/cbdv.202502369.
7. Li S, Wang D, He J, Liao C, Zuo Z, Li S, Niu X. Thermophilic fungus uses anthraquinones to modulate ferrous excretion, sterol-mediated endocytosis, and iron storage in response to cold stress. Microb Biotechnol 2024, 17, e70002.
8. Zhou J, Wang D, Wu Q, Jiang Y, Yan J, Wu L, Li S, Niu X. Rare NRPS Gene cluster for desferriferrichrome biosynthesis controls the conflict between trap formation and nematicidal activity in Arthrobotrys oligospora. J Agric Food Chem 2024, 72, 3560−3571.
9. Li S, He J, Wu Q, Gou J, Wang D, Niu X. Gene fusion and functional diversification of P450 genes facilitate thermophilic fungal adaptation to temperature change, Mycology, 2024, doi: 10.1080/21501203.2024.2324993.
10. Yang XY, Chen YH, Zhang LL, He JB, Wu QF, Li SH, Wang DL, Gou JH, Wu Z, Zhang KQ, Li SH* and Niu XM*. Melanin precursors mediated adaption to Temperature changes in fungus and animals via inhibition of lipid-mediated ferroptosis. Sci China Life Sci 2023, 66(8), 1800-1817. https://doi.org/10.1007/s11427-022-2265-6.
