
杨金奎 研究员,博士生导师
Email:jinkui960@ynu.edu.cn
个人简介:
杨金奎,博士,研究员。2005年至今在云南老员工物资源保护与利用国家重点实验室工作。
本人主要从事捕食线虫真菌侵染线虫的分子机制和应用研究。报道了全球首个捕食线虫真菌的基因组,提出了捕食器官形成的模式图,相关的研究成果被Nature Review Microbiology选为亮点文章进行评述。近5年来聚焦捕器形成的机制,发现了多个调控捕器形态发生的关键蛋白。先后主持国家基金委-云南省联合基金重点项目、国家自然科学基金面上项目、科技部973课题等国家级科研项目9项。获得云南省自然科学奖特等奖 (2015年)、云南省自然科学奖一等奖 (2007、2009和2023年) 和云南省科技进步三等奖 (2012年)。以第一或通讯作者在Biotechnology Advance、Biological Review、Journal of Advanced Research、 PLoS Pathogens、Science China-Life Sciences、Virulence等杂志发表80余篇SCI论文;获得17项国家发明专利授权。入选云南省中青年学术和技术带头人 (2009) 和云南省兴滇英才支持计划云岭学者 (2022)。
招生专业:
微生物学,博士、硕士
生物与医药,博士、硕士(微生物学方向)
研究方向:
近年来围绕捕食线虫真菌与线虫互作机制,重点开展以下研究:
1. 捕食线虫真菌捕食器官形成和形态发育的信号和分子调控机制;
2. 捕食线虫真菌的菌丝分化、产孢和抗逆性的信号和分子调控机制;
3. 捕食线虫真菌的功能基因组和转录组学研究。
代表性研究成果:
1. Liu Q, Jiang K, Duan S, Zhao N, Shen Y, Zhu L, Zhang KQ, Yang J*. 2025. Identification of a transcription factor AoMsn2 of the Hog1 signaling pathway contributes to fungal growth, development and pathogenicity in Arthrobotrys oligospora. Journal of Advanced Research, 2025, 68:1-15.
2. Zhao N, Liu Q, Zhu M, Zhu L, Yang J*. 2025. The Hog1-Nmd5 signaling pathway regulates asexual development, lipid metabolism, stress response, trap morphogenesis, and secondary metabolism of Arthrobotrys oligospora. Virulence, 2025, 16(1):2468294.
3. Yang L, Li X, Ma Y, Zhu M, Zhang KQ, Yang J*. 2024. The Arf-GAPs, AoAge1 and AoAge2, regulate diverse cellular processes, conidiation, trap formation, and secondary metabolism in Arthrobotrys oligospora. Microbiological Research, 2024, 285:127779.
4. Zhu Y, Yang X, Bai N, Liu Q, Yang J*. 2024. AoRab7A interacts with AoVps35 and AoVps41 to regulate vacuole assembly, trap formation, conidiation, and functions of proteasomes and ribosomes in Arthrobotrys oligospora. Microbiological Research, 2024, 280:127573.
5. Wang W, Liu Y, Duan S, Bai N, Zhu M, Yang J*. 2024. Cellular communication and fusion regulate cell fusion, trap morphogenesis, conidiation, and secondary metabolism in Arthrobotrys oligospora. Microbiological Research, 2024, 278:127516.
6. Xie M, Ma N, Bai N, Yang L, Yang X, Zhang KQ*, Yang J*. 2022. PKC-SWI6 signaling regulates asexual development, cell wall integrity, stress response, and lifestyle transition in the nematode-trapping fungus Arthrobotrys oligospora. Science China Life Science, 2022, 65(12):2455-2471.
7. Zhou D, Zhu Y, Bai N, Yang L, Xie M, Yang J, Zhu M, Zhang KQ*, Yang J*. 2022. AoATG5 plays pleiotropic roles in vegetative growth, cell nucleus development, conidiation, and virulence in the nematode-trapping fungus Arthrobotrys oligospora. Science China Life Science, 2022, 65(2):412-425.
8. Yang L, Li X, Bai N, Yang X, Zhang KQ, Yang J*. 2022. Transcriptomic Analysis Reveals That Rho GTPases Regulate Trap Development and Lifestyle Transition of the Nematode-Trapping Fungus Arthrobotrys oligospora. Microbiology Spectrum, 2022, 10(1):e0175921.
9. Liu Q, Li D, Jiang K, Zhang KQ, Yang J*. 2022. AoPEX1 and AoPEX6 Are Required for Mycelial Growth, Conidiation, Stress Response, Fatty Acid Utilization, and Trap Formation in Arthrobotrys oligospora. Microbiology Spectrum, 2022, 10(2):e0027522.
10. Wang W, Zhao Y, Bai N, Zhang KQ, Yang J*. 2022. AMPK Is Involved in Regulating the Utilization of Carbon Sources, Conidiation, Pathogenicity, and Stress Response of the Nematode-Trapping Fungus Arthrobotrys oligospora. Microbiology Spectrum, 2022, 10(4):e0222522.