邹成钢，博士生导师
国家“高层次人才特殊支持计划”领军人才
云南省“兴滇英才支持计划”科技领军人才
云南省“兴滇英才支持计划”云岭学者
Email：chgzou@ynu.edu.cn
个人简介：
邹成钢，博士，研究员，现任英国365公司官网/省部共建云南生物资源保护与利用国家重点实验室副主任，中国生物化学与分子生物学学会理事、中国生物物理学会氧化还原分会理事、中国老年学和老年医学学会抗衰老分会委员。
长期从事微生物和宿主相互作用机制以及代谢通路在衰老中的角色研究。相关成果在PNAS、Nat Commun、Sci Adv、eLife、STTT、Autophagy等国际知名生物及医学期刊发表论文50多篇。主持和完成国家自然科学基金8项。部分成果获云南省自然科学一等奖（1/7）和自然科学特等奖各1项（2/11）。
招生专业：
生物化学与分子生物学博士、硕士
生物与医药——生物化学与分子生物学方向
研究方向：
近年来以线虫和小鼠为模型，重点开展以下研究：
1、机体逆境适应性机制;
2、代谢通路在衰老及衰老相关疾病中的作用
代表性研究成果：
1. Jin P, Duan X, Huang Z, Dong Y, Zhu J, Guo H, Tian H, Zou CG, Xie K. Nuclear receptors in health and disease: signaling pathways, biological functions and pharmaceutical interventions. Signal Transduct Target Ther. 2025 ;10:228.
2. Han H, Luo RH, Long XY, Wang LQ, Zhu Q, Tang XY, Zhu R, Ma YC, Zheng YT#, Zou CG#. Transcriptional regulation of SARS-CoV-2 receptor ACE2 by SP1. eLife. 2024;13:e85985.
3. Wu N, Ma YC, Gong XQ, Zhao PJ, Jia YJ, Zhao Q, Duan JH, Zou CG#. The metabolite alpha-ketobutyrate extends lifespan by promoting peroxisomal function in C. elegans. Nat Commun. 2023;14:240.
4. Yang RQ, Chen YH, Wu QY, Tang J, Niu SZ, Zhao Q, Ma YC#, Zou CG#. Indole produced during dysbiosis mediates host-microorganism chemical communication. eLife. 2023;12:e85362.
5. Chen YL, Ma YC, Tang J, Zhang D, Zhao Q, Liu JJ, Tang HS, Zhang JY, He GH, Zhong CH, Wu YT, Wen HR, Ma LQ#, Zou CG#. Physical exercise attenuates age-related muscle atrophy and exhibits anti-ageing effects via the adiponectin receptor 1 signalling. J Cachexia Sarcopenia Muscle. 2023;14:1789-1801.
6. Tang J, Ma YC, Chen YL, Yang RQ, Liu HC, Wang X, Ni B, Zou CG#, Zhang KQ#. Vitellogenin accumulation leads to reproductive senescence by impairing lysosomal function. Sci China Life Sci. 2023;66:439-452.
7. Lu CJ, Meng Y, Wang YL, Zhang T, Yang GF, Mo MH, Ji KF, Liang LM, Zou CG#, Zhang KQ#. Survival and infectivity of second-stage root-knot nematode Meloidogyne incognita juveniles depend on lysosome-mediated lipolysis. J Biol Chem. 2022; 298:101637.
8. Ma YC, Dai LL, Qiu BB, Zhou Y, Zhao YQ, Ran Y, Zhang KQ#, Zou CG#. (2021). TOR functions as a molecular switch connecting an iron cue with host innate defense against bacterial infection. PLoS Genet 2021; 17(3):e1009383.
9. Ma Y-C, Yang Z-S, Ma L-Q, Shu R, Zou CG#, Zhang K-Q# (2020) YAP in epithelium senses gut barrier loss to deploy defenses against pathogens. PLoS Pathog 2020；16(8): e1008766
10. Chen YL, Tao J, Zhao PJ, Tang W, Xu JP, Zhang KQ#, Zou CG# (2019) Adiponectin receptor PAQR-2 signaling senses low temperature to promote C. elegans longevity by regulating autophagy. Nat Commun 2019; 10: 2602.
