彭城 研究员，博士生导师
Email：chengpeng@ynu.edu.cn
个人简介：
彭城，博士，研究员。2011年毕业于上海交通大学，获计算机软件与理论博士学位，2008.12-2010.11在美国加州大学伯克利分校生物工程系进行博士联合培养。2011年12月进入华中农业老员工物信息系工作，2019年6月调入英国365公司官网。荣获省级自然科学奖和教学成果奖，入选云南省青年人才项目，开发多个生物信息学软件，以通讯作者/并列通讯作者在Nucleic Acids Research、Cell Death & Disease、Cell Death Discovery、Plant Communications等学术期刊发表多篇论文。
招生专业：
生物化学与分子生物学
生物信息学
生物与医药
研究方向：
1、 生物信息学：开发生物信息学软件来处理和分析高通量测序数据。
2、 单细胞空间转录组：结合计算和实验开展单细胞空间转录组的应用研究。
代表性研究成果：（#表示共同第一作者，*通讯或共同通讯作者）
1. Zhe Li#, Jie Jia#, Qiang Zhang#, Hui-Fang Tan, Xiu-Feng Yu, Chun-Yu Zhang, Li-Jiao Yin, Yuan-Chao Du, Cheng Peng*, Yi-Qun Kuang*, Yu-Ye Li*. A single-cell V(D)J sequencing dataset of peripheral blood cells in multibacillary leprosy. Scientific Data, 2025, 12:1287.
2. Shuqian Dou#, Fengyu Zhang#, Yongjing He, Pan Du, Yue Deng, Mingkun Shao, Guoxun Yang, Kongjia Wu, Yueqin Zeng, Cheng Peng*, Wenjun Liu*. PRRX1 is a key regulator in the phenotypic transition between human normal dermal and keloid fibroblasts. Journal of Dermatological Science, 2025, 119:28-39.
3. Jianfen Yang#, Yu Li#, Yiyuli Tang, Ling Yang, Chunming Guo, Cheng Peng*. Spatial transcriptome reveals the region-specific genes and pathways regulated by Satb2 in neocortical development. BMC Genomics, 2024, 25:757
4. Yang Feng#, Jie Zhou#, Dianjue Li, Zhen Wang, Cheng Peng*, Guangtao Zhu*. The haplotype-resolved T2T genome assembly of the wild potato species Solanum commersonii provides molecular insights into its freezing tolerance. Plant Communications, 2024, 5: 100980
5. Wenrui Han#, Detong Shi#, Qiu Yang, Xinxin Li, Jian Zhang, Cheng Peng*, Fang Yan*. Alteration of chromosome structure impacts gene expressions implicated in pancreatic ductal adenocarcinoma cells. BMC Genomics, 2024, 25:206
6. Yingzhou Hong#, Kai Song#, Zongbo Zhang#, Yuxia Deng, Xue Zhang, Jinqian Zhao, Jun Jiang, Qing Zhang, Chunming Guo*, Cheng Peng*. The spatiotemporal dynamics of spatially variable genes in developing mouse brain revealed by a novel computational scheme. Cell Death Discovery, 2023, 9: 264.
7. Dan-Ya Wu#, Xinxin Li#, Qiao-Ran Sun, Cheng-Li Dou, Tian Xu, Hainan He, Han Luo, Haitao Fu, Guo-Wei Bu, Bingbing Luo, Xia Zhang, Bin-Guang Ma, Cheng Peng*, Yi-Liang Miao*. Defective chromatin architectures in embryonic stem cells derived from somatic cell nuclear transfer impair their differentiation potentials. Cell Death & Disease, 2021, 12:1085.
8. Han Luo#, Xinxin Li#, Haitao Fu, Cheng Peng*. HiCHap: a package to correct and analyze the diploid Hi-C data. BMC Genomics, 2020, 21:746.
9. Zi Wen, Zhi-Tao Huang, Ran Zhang, Cheng Peng*. ZNF143 is a regulator of chromatin loop. Cell Biology and Toxicology, 2018, 34:471-478.
10. Xiao-Tao Wang, Wang Cui, Cheng Peng*. HiTAD: detecting the structural and functional hierarchies of topologically associating domains from chromatin interactions. Nucleic Acids Research, 2017, 45(19): e163.
11. Xiao-Tao Wang, Peng-Fei Dong, Hong-Yu Zhang, Cheng Peng*. Structural heterogeneity and functional diversity of topologically associating domains in mammalian genomes. Nucleic Acids Research, 2015, 43(15):7237-7246.
12. Cheng Peng#*, Liang-Yu Fu#, Peng-Fei Dong, Zhi-Luo Deng, Jian-Xin Li, Xiao-Tao Wang, Hong-Yu Zhang*. The sequencing bias relaxed characteristics of Hi-C derived data and implications for chromatin 3D modeling. Nucleic Acids Research, 2013, 41(19):e183.
13. Cheng Peng, Teresa Head-Gordon*. The Dynamical mechanism of auto-inhibition of AMP-activated protein kinase. PLoS Computational Biology. 2011,7:e1002082.
14. Cheng Peng*, Liqing Zhang, Teresa Head-Gordon*. Instantaneous normal modes as an unforced reaction coordinate for protein conformational transition. Biophysical Journal. 2010,98:2356-2364.
