崔清华 教授，硕士生导师
Email：cuiqinghua@ynu.edu.cn
个人简介：
崔清华，博士，教授。本实验室主要关注肿瘤的相关分子调控机理，以细胞株及临床病理样品为材料，集中探讨Bcl-2家族在乳腺癌、结直肠癌、肝癌等的作用机制。发现Bcl-2可以调控线粒体功能，通过其副产物ROS参与细胞周期，并决定癌细胞进入凋亡、焦亡及自噬等不同细胞死亡方式。研究成果发表在JBC、Cell Cycle、Autophagy等国际刊物。
招生专业：
生化与分子生物学硕士
生物与医药——生化与分子生物学方向
研究方向：
1、Bcl-2家族在乳腺癌等癌症中的分子调控机制
2、环境污染物在癌细胞中的毒理作用
代表性研究成果：
1. Ling Xu, Hui Zhou, Yuting Zhong, Linnan Zhao, Jiangying Qian, Lei Ding, Xuexiu Chang, Christopher Kassotis, Qinghua Cui. Zearalenone at environmental levels promoted ER- positive breast cancer cell lines through the hedgehog pathway. Ecotoxicology and Environmental Safety 2025, 303: 118813.
2. Jiangying Qian; Linna Zhao; Ling Xu; Jin Zhao; Yongxu Tang; Min Yu; Jie Lin; Lei Ding; Qinghua Cui. Cell Death: Mechanisms and Potential Targets in Breast Cancer Therapy. International Journal of Molecular Sciences 2024 25(17)：9703.
3. Lingyuan Ma, Chenyu Li, Hanlin Yin, Jiashu Huang, Shenghao Yu, Jin Zhao, Yongxu Tang, Min Yu, Jie Lin, Lei Ding⁎ and Qinghua Cui⁎. The Mechanism of DNA Methylation and miRNA in Breast Cancer. International Journal of Molecular Sciences 2023. 24, 9360
4. Jiaojiao Li, Jiayao Wen, Chunxiao Sun, Yuan Zhou, Jun Xu, Hugh J. MacIsaac, Xuexiu Chang⁎, Qinghua Cui⁎ Phytosphingosine-induced cell apoptosis via mitochondria-mediated pathway. Toxicology 2022. 482, 153370
5. Xufeng Fu, Xiuyu Yang, Xing Du & Qinghua Cui. Deciphering the possible role of H2O2 in methylmercury-induced neurotoxicity in Xenopus laevis. Molecular & Cellular Toxicology, 2020 16:301-309
6. Lei Ding, Jiaqi Cao, Wen Lin, Hongjian Chen, Xianhui Xiong, Hongshun Ao, Min Yu, Jie Lin, Qinghua Cui. The Roles of Cyclin-Dependent Kinases in Cell-Cycle Progression and Therapeutic Strategies in Human Breast Cancer. International Journal of Molecular Sciences 2020. 21:1960.
7.Lei Ding, Huan Gu, Zhenwei Lan, Qingchun Lei, Wenxue Wang, Jie Lin, Min Yu and Qinghua Cui. Down-regulation of cyclooxygenase-1 stimulates mitochondrial apoptosis through NF-kB signaling pathway in Colorectal Cancer Cells. Oncology Reports 2019. 41: 559-569.
8. Du Xing, Fu Xufeng, Yao Kun, Lan Zhenwei, Xu Hui, Cui Qinghua*, Yang Elizabeth. Bcl-2 delays cell cycle through mitochondrial ATP and ROS. Cell Cycle 2017.16(7):707-713.
9. Qinghua Cui, Mayda Valentin, Yelena Janumyan, Elizabeth Yang*. Bax-/- bak-/- cells exhibit p27Thr198 phosphorylation and autophagy. Autophagy 2009. 5 (2): 263-264.
10. Yelena Janumyan#, Qinghua Cui#, Ling Yan, Courtney G. Sansam, Elizabeth Yang*. Go function of BCL2 and BCL-xL requires BAX, BAK, and p27 phosphorylation, revealing a novel role of BAX and BAK in quiescence regulation. JBC 2008. 283: 34108 – 34120.
