姜凯 研究员，博士生导师，东陆骨干教授
深圳市高层次人才、云南省高层次人才
Email：jiangk@ynu.edu.cn
个人简介：
姜凯，博士，研究员，东陆骨干教授。
现任英国365公司官网生物技术系系主任，植物化员工物学课题组组长。
姜凯博士长期从事植物激素信号转导和植物生长发育机制的研究。交叉性地运用经典遗传学、化学遗传学、有机化学、结构生物学、计算化学等多学科方法，湿实验和干实验结合的策略，从事小分子化合物的筛选和理性设计开发。筛选并开发了水杨酸信号抑制剂、赤霉素受体激动剂和拮抗剂、独角金内酯拮抗剂、生长素合成酶和代谢酶抑制剂、转运调控剂以及活性类似物等数十个植物激素相关的小分子化合物。
截至目前，以第一或通讯作者（含共同）在PNAS、Plant Cell、Plant Physiology、Journal Experimental Botany、Journal Integrative Plant Biology等期刊上发表论文15篇。以共同作者身份在Cell、Nature Chemical Biology、Nature Communications、Science Advances等期刊上发表论文15篇。获批专利授权5项。先后主持国家自然科学基金青年和面上项目、云南省面上基金各一项，广东省引进创新创业团队核心成员，以骨干成员身份参与国家自然科学基金重点项目和国际（地区）合作与交流项目。担任Journal of Pesticide Science（SCI收录）海外编委以及Plant Hormones和Advanced AgroChem杂志的青年编委。
招生专业：
生物化学与分子生物学
生物与医药
研究方向：
（1）活性小分子化合物的高通量筛选及其作用机制研究；
（2）运用化学遗传学方法研究植物生长发育和表观遗传调控机制；
（3）新型植物生长调节剂的开发及其在农业中的应用研究;
（4）医药先导化合物的开发。
代表性研究成果：
一作/通讯（含共同）：
1. Xie Y, Zhu Y, Wang N, Luo M, Ota T, Guo R, Yu Z, Aizezi Y, Zhang L, Zhang Y, Bao H, Wang Y, Zhu Z, Huang A, Zhao Y, Asami T, Huang H, Guo H#, and Jiang K#. Chemical genetic screening identifies nalacin as an inhibitor of GH3 amido synthetase for auxin conjugation. Proceedings of the National Academy of Sciences U.S.A. 2022, 119 (49) e2209256119.（中科院1区，Nature Index）
1. Aizezi Y, Zhao H, Zhang Z, Bi Y, Yang Q, Guo G, Zhang H, Guo H, Jiang K# and Wang Z#. Structure-based virtual screening identifies small molecule inhibitors of O-fucosyltransferase SPINDLY. Plant Cell. 2024, 36(3): 479-509. （中科院1区，Nature Index）
2. Ke D, Xie Y, Li H, Hu L, He Y, Guo C, Zhai Y, Guo J, Li K, Chu Z, Zhang J, Zhang X, Al-Balili S, Jiang K#, Miao Y#, Jia K#. Anchorene, a carotenoid-derived growth regulator, modulates auxin homeostasis by suppressing GH3-mediated auxin conjugation. Journal of Integrative Plant Biology. 2024, 66(11): 2490-2504.（中科院1区）
3. Jiang K#, Guo H, and Zhai J#. Interplay of phytohormones and epigenetic regulation: A recipe for plant development and plasticity. Journal of Integrative Plant Biology. 2023, 65(2): 381-298.（中科院1区）
4. Aizezi Y, Shu H, Zhang L, Zhao H, Peng Y, Lan H, Xie Y, Li J, Wang Y, Guo H#, and Jiang K#. Cytokinin regulates apical hook development via the coordinated actions of EIN3/EIL1 and PIF transcription factors in Arabidopsis. Journal of Experimental Botany. 2022, 73(1): 213-227. (封面文章)（中科院1区）
5. Zhu Y, Li H, Su Q, Wen J, Wang Y, Song W, Xie Y, He W, Yang Z, Jiang K#, Guo H#. A phenotype-directed chemical screen identifies ponalrestat as an inhibitor of the plant flavin monooxygenase YUCCA in auxin biosynthesis. Journal of Biological Chemistry. 2019, 294(52): 19923-19933.（中科院2区，Nature Index）
6. Jiang K*, Otani M*, Shimotakahara H, Yoon JM, Park SH, Miyaji T, Nakano T, Nakamura H, Nakajima M, Asami T#. Substituted phthalimide AC94377 is a selective agonist of the gibberellin receptor GID1. Plant Physiology. 2017, 173(1): 825-835.（中科院1区）
7. Takeuchi J*, Jiang K*, Hirabayashi K*, Imamura Y, Wu Y, Xu Y, Miyakawa T, Nakamura H, Tanokura M, Asami T#. Rationally Designed Strigolactone Analogs as Antagonists of the D14 Receptor. Plant and Cell Physiology. 2018, 59(8): 1545-1554.（中科院2区）
8. Jiang K, Kurimoto T, Seo EK, Miyazaki S, Nakajima M, Nakamura H, Asami T#. Development of Inhibitors of Salicylic Acid Signaling. Journal of Agricultural and Food Chemistry. 2015, 63(32): 7124-33.（中科院2区）
共同作者论文
1. Liu L*, Song W*, Huang S, Jiang K, Moriwaki Y, Wang Y, Men Y, Zhang D, Wen X, Han Z, Chai J#, Guo H#. Extracellular pH sensing by plant cell-surface peptide-receptor complexes. Cell. 2022, 185(18), 3341-3355.（中科院1区，Nature Index）
2. Bao H, Zhang B, Zhao Y, Su Y, Peng Y, Yang X, Zhao H, Liu H, Peng J, Pei H, Zhang W, Huang N, Jiang K, Ito M, Liu G, Jork N, Anderson K, Zhao L, Nagata E, Jessen H, Hawkins P, Du C, Rao F#. Oncometabolite 5-IP7 inhibits inositol 5-phosphatase to license E-cadherin endocytosis Nature Chemical Biology. 2025, in press（中科院1区，Nature Index）
3. Liang W, Huang S, Chen X, Jiang K, Gong X, Guo H, Li L. The small molecule Pifithrin–α deactivates ETR1 to repress shade avoidance in Arabidopsis. Science Advances. 2025, in press
4. Wang J, Takahashi I, Kikuzato K, Sakai T, Zhu Z, Jiang K, Nakamura H, Nakano T, Tanokura M, Miyakawa T, Asami T. Identification and structure-guided development of triazole urea-based selective antagonists of Arabidopsis karrikin signaling. Nature Communications. 2025, 16(104).（中科院1区）
5. Chen W, Yan W, Jiang K, Huang H. Molecular insights into DNA recognition by HD-Zip transcription factors. Plant Physiology. 2025, in press.（中科院1区）
6. Liu C, Hao D, Sun R, Zhang Y, Peng Y, Yuan Y, Jiang K, Li W, Wen X#, and Guo H#. Arabidopsis NPF2.13 functions as a critical transporter of bacterial natural compound tunicamycin in plant-microbe interaction. New Phytologist. 2023, 238:765–780.（中科院1区）
7. Watanabe D*, Takahashi I*, Jaroensanti-Tanaka N, Miyazaki S, Jiang K, Nakayasu M, Wada M, Asami T, Mizutani M, Okada K, Nakajima M. The apple gene responsible for columnar tree shape reduces the abundance of biologically active gibberellin. The Plant Journal. 2021, 105:1026-1034.（中科院1区）
8. Nakamura H*, Hirabayashi K*, Miyakawa T, Kikuzato K, Hu W, Xu Y, Jiang K, Takahashi I, Niiyama R, Dohmae N, Tanokura M, Asami T. #. Triazole ureas covalently bind to strigolactone receptor and antagonize strigolactone responses. Molecular Plant. 2019, 12(1):44-58.（1区）
9. Jamil M, Kountche BA, Haider I, Guo X, Ntui VO, Jia KP, Ali S, Hameed US, Nakamura H, Lyu Y, Jiang K, Hirabayashi K, Tanokura M, Arold ST, Asami T, Al-Babili S#. Methyl phenlactonoates are efficient strigolactone analogs with simple structure. Journal of Experimental Botany. 2018, 69(9):2319-2331.（中科院1区）
10. Zheng L, Meng J, Jiang K, Lan H, Wang Z, Lin M, Li W, Guo H, Wei Y#, and Mu Y#. Improving protein-ligand docking and screening accuracies by incorporating a scoring function correction term. Briefings in Bioinformatics. 2022, 23(3), 1–15.（中科院1区）
(*第一作者, #通讯作者)
